The serotonin transporter-imipramine "receptor".
نویسندگان
چکیده
منابع مشابه
Dithiothreithol promotes a higher affinity state of the serotonin transporter for the tricyclic antidepressant, imipramine.
Neurotransmitter transporters are present in nerve terminal membranes and are responsible for the inactivation of released neurotransmitter by reuptake. One such transporter is the serotonin transporter which also represents the site of action of many clinically used tricyclic antidepressants, such as imipramine. Recently, most of the known Na+-dependent neurotransmitter transporters have been ...
متن کاملEvidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes.
Serotonin is actively transported into brush-border membrane vesicles isolated from normal human term placentas and an inward-directed NaCl gradient provides the driving force for this process. Uptake is negligible if Na+ is replaced by Li+, K+, Rb+, Cs+ or choline. The presence of Cl- seems necessary for the maximal activity of this Na+-dependent uptake system. Intravesicular K+ (20-40 mM) sti...
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BACKGROUND The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) may impact on the in-vivo binding of important serotonergic structures such as the serotonin transporter (5-HTT) and the serotonin-1A (5-HT1A) receptor. Previous positron emission tomography (PET) studies on the association between Val66Met and 5-HTT and 5-HT1A binding potential (BPND) have demonstrated equiv...
متن کاملT Serotonin Transporter :
April 2004 Volume 4, Issue 2 Dennis L. Murphy, Alicja Lerner, Gary Rudnick, and Klaus-Peter Lesch Laboratory of Clinical Science, Building 10, Room 3D41, 10 Center Drive, MSC 1264, NIMH, NIH, Bethesda, MD 20892; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510; Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Würz...
متن کاملReceptor mediation of exaggerated responses to serotonin-enhancing drugs in serotonin transporter (SERT)-deficient mice.
Administration of serotonin-enhancing drugs induces a distinctive behavioral syndrome in rodents. We previously reported that mice with a targeted disruption of the serotonin transporter (SERT) display some of these behaviors spontaneously, in the absence of drug. In the current studies, we assessed the drug-induced serotonin syndrome in SERT wildtype (+/+), heterozygous (+/-) and knockout (-/-...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1983
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)32380-9